abstract：Background:Delirium is common in hospitalized patients and is associated with worse outcomes. Antipsychotics are commonly used; however, the associated benefits and harms are unclear. Purpose:To conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults. Data Sources:P...

journal_title：Annals of internal medicine

authors： Nikooie R,Neufeld KJ,Oh ES,Wilson LM,Zhang A,Robinson KA,Needham DM

更新日期：2019-10-01 00:00:00

abstract：Background:Central line-associated bloodstream infection (CLABSI) remains prevalent in hospitals in the United States. Objective:To evaluate the impact of a multimodal intervention in hospitals with elevated rates of health care-associated infection. Design:Pre-post observational evaluation of a prospective, national...

journal_title：Annals of internal medicine

authors： Patel PK,Greene MT,Jones K,Rolle AJ,Ratz D,Snyder A,Saint S,Chopra V

更新日期：2019-10-01 00:00:00

abstract：Background:Cardiovascular implantable electronic devices (CIEDs) are associated with procedure-related complications, yet little is known about variation in complication rates among institutions that may suggest disparities in care quality. Objective:To assess institutional variation in risk-standardized complication ...

journal_title：Annals of internal medicine

authors： Ranasinghe I,Labrosciano C,Horton D,Ganesan A,Curtis JP,Krumholz HM,McGavigan A,Hossain S,Air T,Hariharaputhiran S

更新日期：2019-09-03 00:00:00

abstract：Background:Whether statin type influences hepatocellular carcinoma (HCC) incidence or mortality in chronic hepatitis B or C virus infection is unknown. Objective:To assess the relationship between lipophilic or hydrophilic statin use and HCC incidence and mortality in a nationwide population with viral hepatitis. Des...

journal_title：Annals of internal medicine

authors： Simon TG,Duberg AS,Aleman S,Hagstrom H,Nguyen LH,Khalili H,Chung RT,Ludvigsson JF

更新日期：2019-09-03 00:00:00

abstract：:Deaths and injuries from firearms are significant public health problems, and clinicians are in a unique position to identify risk among their patients and discuss the importance of safe firearm practices. Although clinicians may be ill-prepared to engage in such discussions, an adequate body of evidence is available ...

journal_title：Annals of internal medicine

authors： Pallin R,Spitzer SA,Ranney ML,Betz ME,Wintemute GJ

更新日期：2019-06-04 00:00:00

abstract：Background:Patients desire information about health care costs because they are increasingly responsible for these costs. Public Web sites that offer cost information could inform provider-patient discussions of costs at the point of care. Objective:To evaluate tools to facilitate the use of publicly available cost in...

journal_title：Annals of internal medicine

authors： Fox KS,Gray CE,Williamson ME,MacKenzie JA

更新日期：2019-05-07 00:00:00

abstract：:Medicine has long sought to match diagnostic and treatment approaches to the particular needs and risks of individual patients. The decreasing cost and increasing ease of genetic sequencing have propelled the rise of precision medicine. Precision medicine aims to use genetic and other information to provide care tailo...

journal_title：Annals of internal medicine

authors： Kiryluk K,Goldstein DB,Rowe JW,Gharavi AG,Wapner R,Chung WK

更新日期：2019-05-07 00:00:00

abstract：Background:More than half of enrollees in the U.S. Department of Veterans Affairs (VA) are also covered by Medicare and can choose to receive their prescriptions from VA or from Medicare-participating providers. Such dual-system care may lead to unsafe opioid use if providers in these 2 systems do not coordinate care o...

journal_title：Annals of internal medicine

authors： Moyo P,Zhao X,Thorpe CT,Thorpe JM,Sileanu FE,Cashy JP,Hale JA,Mor MK,Radomski TR,Donohue JM,Hausmann LRM,Hanlon JT,Good CB,Fine MJ,Gellad WF

更新日期：2019-04-02 00:00:00

abstract：Background:Many prognostic models for cardiovascular risk can be used to estimate aspirin's absolute benefits, but few bleeding risk models are available to estimate its likely harms. Objective:To develop prognostic bleeding risk models among persons in whom aspirin might be considered for the primary prevention of ca...

journal_title：Annals of internal medicine

authors： Selak V,Jackson R,Poppe K,Wu B,Harwood M,Grey C,Pylypchuk R,Mehta S,Kerr A,Wells S

更新日期：2019-03-19 00:00:00

abstract：Background:As cardiovascular risk increases in China, interest in strategies to mitigate it is growing. However, national information about the prevalence and treatment of high cardiovascular disease (CVD) risk is limited. Objective:To assess the prevalence and treatment of high CVD risk as well as variations in risk ...

journal_title：Annals of internal medicine

authors： Lu J,Lu Y,Yang H,Bilige W,Li Y,Schulz W,Masoudi FA,Krumholz HM

更新日期：2019-03-05 00:00:00

abstract：Background:Stroke rates in patients with nonvalvular atrial fibrillation (AF) who are not receiving anticoagulant therapy vary widely across published studies; the resulting effect on the net clinical benefit of anticoagulation in AF is unknown. Objective:To determine the effect of variation in published AF stroke rat...

journal_title：Annals of internal medicine

authors： Shah SJ,Eckman MH,Aspberg S,Go AS,Singer DE

更新日期：2018-10-16 00:00:00

abstract：Description:Recommendation on screening for urinary incontinence in women by the Women's Preventive Services Initiative (WPSI), a national coalition of women's health professional organizations and patient representatives. The WPSI's recommendations are intended to guide clinical practice and coverage of services for t...

journal_title：Annals of internal medicine

authors： O'Reilly N,Nelson HD,Conry JM,Frost J,Gregory KD,Kendig SM,Phipps M,Salganicoff A,Ramos D,Zahn C,Qaseem A,Women's Preventive Services Initiative.

更新日期：2018-09-04 00:00:00

abstract：Background:Probiotics, prebiotics, and synbiotics are used increasingly, although the safety and potential harms of these interventions are poorly understood. Purpose:To examine how harms-related information is reported in publications of randomized controlled trials (RCTs) of probiotics, prebiotics, and synbiotics. ...

journal_title：Annals of internal medicine

authors： Bafeta A,Koh M,Riveros C,Ravaud P

更新日期：2018-08-21 00:00:00

abstract：:Research on assessing or managing medication adherence applies approaches from observational, interventional, and implementation science that spans many disciplines and demands coherent conceptualization, valid methods, appropriate analyses, and complete and accurate reporting. To ensure such reporting, the European S...

journal_title：Annals of internal medicine

authors： De Geest S,Zullig LL,Dunbar-Jacob J,Helmy R,Hughes DA,Wilson IB,Vrijens B

更新日期：2018-07-03 00:00:00

abstract：Background:The 2013 pooled cohort equations (PCEs) are central in prevention guidelines for cardiovascular disease (CVD) but can misestimate CVD risk. Objective:To improve the clinical accuracy of CVD risk prediction by revising the 2013 PCEs using newer data and statistical methods. Design:Derivation and validation ...

journal_title：Annals of internal medicine

authors： Yadlowsky S,Hayward RA,Sussman JB,McClelland RL,Min YI,Basu S

更新日期：2018-07-03 00:00:00

abstract：:Women comprise more than one third of the active physician workforce, an estimated 46% of all physicians-in-training, and more than half of all medical students in the United States. Although progress has been made toward gender diversity in the physician workforce, disparities in compensation exist and inequities hav...

journal_title：Annals of internal medicine

authors： Butkus R,Serchen J,Moyer DV,Bornstein SS,Hingle ST,Health and Public Policy Committee of the American College of Physicians.

更新日期：2018-05-15 00:00:00

abstract：:Much of what is formally taught in medicine is about the knowledge, skills, and behaviors required of a physician, including how to express compassion and respect for patients at the bedside. What is learned, however, includes not only admirable qualities but also behaviors and qualities that are inconsistent with eth...

journal_title：Annals of internal medicine

authors： Lehmann LS,Sulmasy LS,Desai S,ACP Ethics, Professionalism and Human Rights Committee.

更新日期：2018-04-03 00:00:00

abstract：Description:The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a selective update of the prior CKD-MBD guideline published in 2009. The guideline update an...

journal_title：Annals of internal medicine

authors： Ketteler M,Block GA,Evenepoel P,Fukagawa M,Herzog CA,McCann L,Moe SM,Shroff R,Tonelli MA,Toussaint ND,Vervloet MG,Leonard MB

更新日期：2018-03-20 00:00:00

abstract：:Palliative care prioritizes symptom management and quality of life throughout the course of serious illness. Regardless of whether care is inpatient or outpatient, primary or subspecialty, a solid understanding of the basics of effective communication, symptom management, and end-of-life care is crucial. This article ...

journal_title：Annals of internal medicine

authors： Swetz KM,Kamal AH

更新日期：2018-03-06 00:00:00

abstract：Background:Difficulties with daily functioning are common in middle-aged adults. However, little is known about the epidemiology or clinical course of these problems, including the extent to which they share common features with functional impairment in older adults. Objective:To determine the epidemiology and clinica...

journal_title：Annals of internal medicine

authors： Brown RT,Diaz-Ramirez LG,Boscardin WJ,Lee SJ,Steinman MA

更新日期：2017-12-05 00:00:00

abstract：:Aspirin exerts antiplatelet effects through irreversible inhibition of cyclooxygenase-1, whereas its anticancer effects may be due to inhibition of cyclooxygenase-2 and other pathways. In 2009, the U.S. Preventive Services Task Force endorsed aspirin for primary prevention of cardiovascular disease. However, aspirin's...

journal_title：Annals of internal medicine

authors： Burns RB,Graham K,Sawhney MS,Reynolds EE

更新日期：2017-12-05 00:00:00

abstract：Background:Bone health is a significant concern in men with prostate cancer. Purpose:To evaluate the effectiveness of drug, supplement, and lifestyle interventions aimed at preventing fracture, improving bone mineral density (BMD), or preventing or delaying osteoporosis in men with nonmetastatic prostate cancer. Data...

journal_title：Annals of internal medicine

authors： Alibhai SMH,Zukotynski K,Walker-Dilks C,Emmenegger U,Finelli A,Morgan SC,Hotte SJ,Tomlinson GA,Winquist E

更新日期：2017-09-05 00:00:00

abstract：Background:Implantable cardioverter-defibrillators (ICDs) have a role in preventing cardiac arrest in patients at risk for life-threatening ventricular arrhythmias. Purpose:To compare ICD therapy with conventional care for the primary prevention of death of various causes in adults with ischemic or nonischemic cardiom...

journal_title：Annals of internal medicine

authors： Kolodziejczak M,Andreotti F,Kowalewski M,Buffon A,Ciccone MM,Parati G,Scicchitano P,Uminska JM,De Servi S,Bliden KP,Kubica J,Bortone A,Crea F,Gurbel P,Navarese EP

更新日期：2017-07-18 00:00:00

abstract：:Chinese herbal medicine (CHM) formulas are the major components of traditional Chinese medicine (TCM) interventions. The general reporting quality of randomized controlled trials (RCTs) of CHM formulas is disappointing, although CONSORT (Consolidated Standards of Reporting Trials) Statement extensions for herbal medic...

journal_title：Annals of internal medicine

authors： Cheng CW,Wu TX,Shang HC,Li YP,Altman DG,Moher D,Bian ZX,CONSORT-CHM Formulas 2017 Group.

更新日期：2017-06-27 00:00:00

abstract：Background:The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and ...

journal_title：Annals of internal medicine

authors： Berkhemer OA,Borst J,Kappelhof M,Yoo AJ,van den Berg LA,Fransen PSS,Beumer D,Schonewille WJ,Nederkoorn PJ,Wermer MJH,Marquering HA,Lingsma HF,Roos YBWEM,van Oostenbrugge RJ,Dippel DWJ,van Zwam WH,Majoie CBLM,Emmer BJ,

更新日期：2017-06-20 00:00:00

abstract：Background:The 2013 cholesterol management guidelines from the American College of Cardiology and American Heart Association (ACC/AHA) recommend lipid screening in all adults older than 20 years to identify those at increased risk for atherosclerotic cardiovascular disease (ASCVD). Statins may be considered for patient...

journal_title：Annals of internal medicine

authors： Patel KK,Taksler GB,Hu B,Rothberg MB

更新日期：2017-06-20 00:00:00

abstract：Background:High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI). Purpose:To estimate the ability of a single hs-cTnT concentration below the limit of detection (<0.005 µg/L) and a nonischemic electrocardiogram (ECG) to rule out AMI in adults ...

journal_title：Annals of internal medicine

authors： Pickering JW,Than MP,Cullen L,Aldous S,Ter Avest E,Body R,Carlton EW,Collinson P,Dupuy AM,Ekelund U,Eggers KM,Florkowski CM,Freund Y,George P,Goodacre S,Greenslade JH,Jaffe AS,Lord SJ,Mokhtari A,Mueller C,Munro A

更新日期：2017-05-16 00:00:00

abstract：Background:A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available. Purpose:To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicular or radicular low back pain. Data Sources:Ov...

journal_title：Annals of internal medicine

authors： Chou R,Deyo R,Friedly J,Skelly A,Weimer M,Fu R,Dana T,Kraegel P,Griffin J,Grusing S

更新日期：2017-04-04 00:00:00

abstract：Background:The benefits of pay-for-performance (P4P) programs are uncertain. Purpose:To update and expand a prior review examining the effects of P4P programs targeted at the physician, group, managerial, or institutional level on process-of-care and patient outcomes in ambulatory and inpatient settings. Data Sources...

journal_title：Annals of internal medicine

authors： Mendelson A,Kondo K,Damberg C,Low A,Motúapuaka M,Freeman M,O'Neil M,Relevo R,Kansagara D

更新日期：2017-03-07 00:00:00

abstract：Background:In 1994, 40% of U.S. gun owners who had recently acquired a firearm did so without a background check. No contemporary estimates exist. Objective:To estimate the proportion of current U.S. gun owners who acquired their most recent firearm without a background check, by time since and manner of acquisition, ...

journal_title：Annals of internal medicine

authors： Miller M,Hepburn L,Azrael D

更新日期：2017-02-21 00:00:00

abstract：Background:Little is known about whether insurance expansion affects the location and type of emergency department (ED) use. Understanding these changes can inform state-level decisions about the Medicaid expansion under the Patient Protection and Affordable Care Act (ACA). Objective:To investigate the effect of the 2...

journal_title：Annals of internal medicine

authors： Garthwaite C,Gross T,Notowidigdo M,Graves JA

更新日期：2017-02-07 00:00:00

abstract：Background:Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective:To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design:Descriptive, using GeoSentinel records. Setting:63 travel and t...

journal_title：Annals of internal medicine

authors： Hamer DH,Barbre KA,Chen LH,Grobusch MP,Schlagenhauf P,Goorhuis A,van Genderen PJ,Molina I,Asgeirsson H,Kozarsky PE,Caumes E,Hagmann SH,Mockenhaupt FP,Eperon G,Barnett ED,Bottieau E,Boggild AK,Gautret P,Hynes NA,Kuhn

更新日期：2017-01-17 00:00:00

abstract：Background:High-risk human papillomavirus (hrHPV) testing to triage women with minor cervical lesions generates many referrals. Purpose:To evaluate the accuracy of genotyping for HPV types 16 and 18 and its utility as a second triage step after hrHPV testing in women with minor cervical lesions. Data Sources:Searches...

journal_title：Annals of internal medicine

authors： Arbyn M,Xu L,Verdoodt F,Cuzick J,Szarewski A,Belinson JL,Wentzensen N,Gage JC,Khan MJ

更新日期：2017-01-17 00:00:00

abstract：:The latest guidelines from the American College of Cardiology and American Heart Association, released in fall 2013, provide a long-anticipated update to the recommendations of the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol ...

journal_title：Annals of internal medicine

authors： Cook NR,Ridker PM

更新日期：2016-12-06 00:00:00

abstract：Background:Little is known about how physician time is allocated in ambulatory care. Objective:To describe how physician time is spent in ambulatory practice. Design:Quantitative direct observational time and motion study (during office hours) and self-reported diary (after hours). Setting:U.S. ambulatory care in 4 ...

journal_title：Annals of internal medicine

authors： Sinsky C,Colligan L,Li L,Prgomet M,Reynolds S,Goeders L,Westbrook J,Tutty M,Blike G

更新日期：2016-12-06 00:00:00

abstract：Background:Frailty assessment may inform surgical risk and prognosis not captured by conventional surgical risk scores. Purpose:To evaluate the evidence for various frailty instruments used to predict mortality, functional status, or major adverse cardiovascular and cerebrovascular events (MACCEs) in older adults unde...

journal_title：Annals of internal medicine

authors： Kim DH,Kim CA,Placide S,Lipsitz LA,Marcantonio ER

更新日期：2016-11-01 00:00:00

abstract：Background:Biosimilars are of growing clinical, regulatory, and commercial importance. Purpose:To summarize evidence about the bioequivalence between biosimilar and reference tumor necrosis factor-α (TNF-α) inhibitors. Data Sources:PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and LILACS from incept...

journal_title：Annals of internal medicine

authors： Chingcuanco F,Segal JB,Kim SC,Alexander GC

更新日期：2016-10-18 00:00:00

abstract：Background:Acute pancreatitis (AP) varies in severity, prompting development of systems aimed at predicting prognosis to help guide therapy. Although several prediction approaches are available, their test characteristics and clinical utility are not completely understood. Purpose:To evaluate the test characteristics ...

journal_title：Annals of internal medicine

authors： Di MY,Liu H,Yang ZY,Bonis PA,Tang JL,Lau J

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Pharmaceutical companies and other trial sponsors must submit certain trial results to ClinicalTrials.gov. The validity of these results is unclear. PURPOSE:To validate results posted on ClinicalTrials.gov against publicly available U.S. Food and Drug Administration (FDA) reviews on Drugs@FDA. DATA SOURCES...

journal_title：Annals of internal medicine

authors： Schwartz LM,Woloshin S,Zheng E,Tse T,Zarin DA

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 global treatment target aims to achieve 73% virologic suppression among HIV-infected persons worldwide by 2020. OBJECTIVE:To estimate the clinical and economic value of reaching this ambitious goal in South Africa, by using a microsimulation m...

journal_title：Annals of internal medicine

authors： Walensky RP,Borre ED,Bekker LG,Resch SC,Hyle EP,Wood R,Weinstein MC,Ciaranello AL,Freedberg KA,Paltiel AD

更新日期：2016-09-06 00:00:00